abstract：:Ready dosage form (eye drops) prepared on the basis of recombinant alpha2-IFN exhibits high activity towards herpes simplex type 1 virus in vitro. Systematic study of the antiherpesvirus effect of this drug in combination with modified nucleosides showed an inhibitory effect of the synergic type. Combination of IFN pr...

journal_title：Bulletin of experimental biology and medicine

authors： Vyzhlova EN,Andronova VL,Galegov GA,Malinovskaya VV

更新日期：2006-06-01 00:00:00

abstract：:A new chromatographic procedure is proposed for rapid (35 min) complete fractionation of flavonoids in plant raw material; the method well discriminates between components with antioxidant activity (rutin, apigenin, quercetin, hesperidin). The method is based on reverse-phase high performance liquid chromatography usi...

journal_title：Bulletin of experimental biology and medicine

authors： Markaryan AA

更新日期：2006-06-01 00:00:00

abstract：:The interaction between dopamine D1 and D2 receptors plays a role in immunomodulation. The results of thus interaction depends on the degree of receptor activation with selective agonists in different doses. Combined treatment with agonists of D1 and D2 receptors in high doses had a synergistic effect in the mechanism...

journal_title：Bulletin of experimental biology and medicine

authors： Devoino LV,Al'perina EL,Gevorgyan MM,Cheido MA

更新日期：2006-05-01 00:00:00

abstract：:We evaluated the concentration dependence and time dependence of the effect of nitroglycerine on intracellular content of cAMP, cGMP, and free Ca2+. It was shown that after norepinephrine stimulation, nitroglycerine exhibited calcium-blocking activity in lower concentrations (starting from 10(-7) M). Under conditions ...

journal_title：Bulletin of experimental biology and medicine

authors： Dukhanin AS,Shimanovskii NL

更新日期：2006-05-01 00:00:00

abstract：:Experiments on "stationary aging" cultures of B11dii-FAF28 Chinese hamster cells showed that contact inhibition of cell growth and further culturing of cells in the stationary phase led to continuous inhibition of enzymes realizing poly-ADP-ribosylation of chromatin proteins. Cell density in the monolayer and percenta...

journal_title：Bulletin of experimental biology and medicine

authors： Shram SI,Shilovskii GA,Khokhlov AN

更新日期：2006-05-01 00:00:00

abstract：:The prooxidant-antioxidant balance in rats with oxidative stress was studied during correction of the L-arginine-NO system. Oxidative stress was induced by intravenous injection of E. coli lipopolysaccharide. Under conditions of oxidative stress the prooxidant-antioxidant imbalance was least pronounced during selectiv...

journal_title：Bulletin of experimental biology and medicine

authors： Glebov AN,Zinchuk VV

更新日期：2006-04-01 00:00:00

abstract：:Ten-minute perfusion of intact isolated rat heart with Krebs-Henseleit solution containing delta-opioid receptor agonists (DPDPE, (-)-TAN-67) or delta-opioid receptor antagonists (naltrindole, TIPP[psi], ICI 174,864) at a final concentration of 0.1 mg/liter decreased HR, blood pressure in the left ventricle, and the r...

journal_title：Bulletin of experimental biology and medicine

authors： Maslov LN,Lishmanov YB,Barzakh EI,Lasukova TV,Rice KK,Oeltgen PR

更新日期：2006-04-01 00:00:00

abstract：:Formation of Ala-Glu-Asp-Gly peptide complex with duplex DNA [poly(dA-dT):poly(dA-dT)] at neutral pH and ambient temperature was studied experimentally. Peptide binding to duplex DNA was associated with hyperchromic effect indicating local separation of the double helix. Energies of paired interactions between amino a...

journal_title：Bulletin of experimental biology and medicine

authors： Khavinson VKh,Solovyov AY,Shataeva LK

更新日期：2006-04-01 00:00:00

abstract：:The myogenic differentiation capacity of prenatal mesenchymal stem cells from the main sites of hemopoiesis (bone marrow, thymus, liver, and spleen) was studied. Myogenesis was observed in all studied cell cultures except splenic mesenchymal stem cells. Differentiating cells from the thymus, bone marrow, and liver wer...

journal_title：Bulletin of experimental biology and medicine

authors： Gornostaeva SN,Rzhaninova AA,Gol'dstein DV

更新日期：2006-04-01 00:00:00

abstract：:Effects of pentobarbital on spectral characteristics and phase ratios of wave oscillations of the cardiac contraction period (RR interval) and time of atrioventricular conduction (AV interval) were studied in experiments of cats. Pentobarbital moderately reduced the mean values of both intervals and significantly redu...

journal_title：Bulletin of experimental biology and medicine

authors： Alipov NN,Sergeeva OV,Smirnov VM,Kuznetsova TE,Bobrova NA

更新日期：2006-03-01 00:00:00

abstract：:The dependence of daily vitamin excretion with breast milk on dietary vitamin content and blood vitamin level was studied in nursing women. Breast mils vitamins were assayed in women supplied with vitamins. We identified the criteria for adequate vitamin supply in nursing women over the 1st month after labor (vitamins...

journal_title：Bulletin of experimental biology and medicine

authors： Kodentsova VM,Vrzhesinskaya OA

更新日期：2006-03-01 00:00:00

abstract：:We studied the effect of Herceptin therapy on the population composition of lymphocytes and percentage of CD4+CD25+ cells (regulatory T cells) in breast cancer patients. Herceptin treatment decreased the number of "professional" T suppressors (CD4+CD25+ cells and regulatory T cells) in the peripheral blood. ...

journal_title：Bulletin of experimental biology and medicine

authors： Slavina EG,Chertkova AI,Zabotina TN,Gan'shina IP,Lichinitser MR

更新日期：2006-03-01 00:00:00

abstract：:The hydruric response to water load in Wistar rats and homozygous Brattleboro rats with a hereditary defect in the synthesis of vasopressin was studied under conditions of increased brain serotonin level. Serotonin prevented the reduction in reabsorption of osmotically free water in normal rats, but had no effect in v...

journal_title：Bulletin of experimental biology and medicine

authors： Ivanova LN,Kochkaeva LN,Melidi NN

更新日期：2006-02-01 00:00:00

abstract：:The concentrations of vascular endothelial growth factor and endothelin in the placenta progressively increased during normal pregnancy. Production of vascular endothelial growth factor and endothelin in the placenta exceeded the normal during trimester I miscarriage and trimester III premature birth accompanied by in...

journal_title：Bulletin of experimental biology and medicine

authors： Krukier II,Pogorelova TN

更新日期：2006-02-01 00:00:00

abstract：:We studied the effects of optical (dd-, ll-, dl-, and ld-dipeptides with alpha-bond, EW) structural isomers and cyclic (dd-, ll-, dl-, and ld-dipeptides with gamma-bond, iEW) analogs of Glu-Trp synthetic dipeptide on the population of normal hemopoietic stem cells. Dipeptides containing lGlu (lGlu-lTrp, lGlu-dTrp) inj...

journal_title：Bulletin of experimental biology and medicine

authors： Semina OV,Semenets TN,Zamulaeva IA,Selivanova EI,Malyutina YV,Saenko AS,Deigin VI

更新日期：2006-02-01 00:00:00

abstract：:We studied the interaction between the sympathetic and parasympathetic parts of the autonomic nervous system in the regulation of smooth muscles in the femoral artery and trachea. It was shown that this regulation involves ganglionic serotoninergic neurons transmitting excitation to 5-HT, receptors in the effector tis...

journal_title：Bulletin of experimental biology and medicine

authors： Lazebnik LB,Lychkova AE

更新日期：2006-01-01 00:00:00

abstract：:Lipophilic inhibitors of angiotensin-converting enzyme increased 6-month survival and/or lifetime of rats with experimental chronic heart failure. These drugs had no effect on the mortality rate of animals with acute decompensation of the disease. beta-Adrenoceptor blockers without intrinsic sympathomimetic activity n...

journal_title：Bulletin of experimental biology and medicine

authors： Fedorov VN,Sal'nikov EV,Sidorov AV,Bogatushin AV,Fateev MM

更新日期：2006-01-01 00:00:00

abstract：:The qualitative and quantitative differences in lipids composition were found in chromatin fractions differing by attachment to the nuclear matrix and transcriptional activity. During liver regeneration after partial hepatectomy Changes in the lipid spectrum of chromatin fractions in G1- and S-phases are associated wi...

journal_title：Bulletin of experimental biology and medicine

authors： Trofimov VA,Dudko AA

更新日期：2006-01-01 00:00:00

abstract：:Immunophenotype of human bone marrow mesenchymal stem cells was studied after several culturing passages and after cryopreservation. Immunocytochemical analysis showed that bone marrow mesenchymal stem cells acquired homogeneity during in vitro culturing, but initially contained heterogeneous populations. ...

journal_title：Bulletin of experimental biology and medicine

authors： Lagar'kova MA,Lyakisheva AV,Filonenko ES,Volchkov PY,Rubtsova KV,Gerasimov YV,Chailakhyan RK,Kiselev SL

更新日期：2006-01-01 00:00:00

abstract：:We estimated the percentage of CD4+ lymphocytes synthesizing IFN-gamma and IL-4 in the peripheral blood and measured the concentrations of IL-1, IL-6, and TNF-alpha in lochia of patients with postpartum endometritis. T lymphocytes with intracellular IFN-gamma prevailed in women with physiological course of the postpar...

journal_title：Bulletin of experimental biology and medicine

authors： Sukhikh GT,Kasabulatov NM,Van'ko LV,Ordzhonikidze NV,Veryasov VN,Danelyan SZh

更新日期：2005-12-01 00:00:00

abstract：:We studied the seasonal effects of peptide preparation Selank on orientation and exploratory activity in 36 arctic ground squirrels Citellus undulatus in the open-field and hole-board tests. Selank most significantly increased behavioral activity of hibernating animals in the spring and fall. The test peptide had no e...

journal_title：Bulletin of experimental biology and medicine

authors： Semenova TP,Kozlovskaya MM,Zuikov AV,Kozlovskii II,Andreeva LA

更新日期：2005-12-01 00:00:00

abstract：:A direct relationship between the weights of the brain and hemisphere and parameters characterizing the development of the cortex and its neurons in intact newborn rats was revealed. Parameters of brain development in newborn rats correlate with 3beta-hydroxysteroid dehydrogenase activity in the adrenal zona glomerulo...

journal_title：Bulletin of experimental biology and medicine

authors： Ryzhavskii BY,Matveeva EP,Baranova SN

更新日期：2005-12-01 00:00:00

abstract：:We studied electrophysiological parameters and morphological changes in the adrenal glands and spleen of CBA mice feeding a low-choline diet and/or ethanol-containing diet. The polarization coefficient underwent similar changes in the adrenal glands and spleen, which was associated with different contribution of imped...

journal_title：Bulletin of experimental biology and medicine

authors： Tornuev YV,Nepomnyashchikh LM,Koldysheva EV

更新日期：2005-11-01 00:00:00

abstract：:The concentrations of proinflammatory cytokines (IL-1beta, IL-6), vascular endothelium growth factor, tumor growth factor-beta, and insulin-like growth factor-1 were measured in the peritoneal fluid of patients with external genital endometriosis and healthy women by enzyme immunoassay. The effect of peritoneal fluid ...

journal_title：Bulletin of experimental biology and medicine

authors： Sokolov DI,Solodovnikova NG,Pavlov OV,Niauri DA,Volkov NN,Sel'kov SA

更新日期：2005-11-01 00:00:00

abstract：:Experiments on rats showed that high-intensity light exposure (6000 lux, 6 h) caused focal injuries in the retina. The most sensitive structures were neurosensory cells, pigmented epithelium, radial gliocytes, and choroid capillaries. Injection of ascovertin led to disappearance of foci of injuries, limited blood supp...

journal_title：Bulletin of experimental biology and medicine

authors： Logvinov SV,Plotnikov MB,Varakuta EY,Zhdankina AA,Potapov AV,Mikhulya EP

更新日期：2005-11-01 00:00:00

abstract：:We studied the effect of bone marrow Thy 1,2+ cells on the growth of erythroid colonies and the role of monoamine in the regulation of proliferation and differentiation of erythroid precursor cells in experimental neuroses. Under conditions of conflict situation Thy 1,2+ cells stimulated the growth of erythropoietic p...

journal_title：Bulletin of experimental biology and medicine

authors： Skurikhin EG,Provalova NV,Pershina OV,Minakova MY

更新日期：2005-11-01 00:00:00

abstract：:We measured activity of angiotensin-converting enzyme in plasma and tissue of NISAG and normotensive WAG rats. In different organs of NISAG rats, activity of this enzyme did not differ from the corresponding values of WAG rats, although enzyme activity in the plasma of NISAG rats was significantly lower than that of W...

journal_title：Bulletin of experimental biology and medicine

authors： Cherkasova OP,Fedorov VI,Markel AL

更新日期：2005-10-01 00:00:00

abstract：:Modification of apolipoprotein B-100 conformation on the surface of LDL isolated from human blood was demonstrated by enzyme immunoassay with a panel of monoclonal antibodies to this protein. The study by the light transmission fluctuation method showed that incubation of LDL with phospholipases A2 or C led to associa...

journal_title：Bulletin of experimental biology and medicine

authors： Aksenov DV,Mel'nichenko AA,Suprun IV,Yanushevskaya EV,Vlasik TN,Sobenin IA,Panasenko OM,Orekhov AN

更新日期：2005-10-01 00:00:00

abstract：:Correlation between changes in activity of intracellular Ca(2+)-activated proteinases and cholesterol content in mussels in response to changes in habitat saltiness was detected in mollusks from littoral and sublittoral White sea zones. Calpain activity in mussels decreased in low water saltiness and increased in high...

journal_title：Bulletin of experimental biology and medicine

authors： Kyaivyaryainen EI,Nefedova ZA,Bondareva LA,Alekseeva NN,Nemova NN

更新日期：2005-10-01 00:00:00

abstract：:We studied the effect of single intraperitoneal treatment with antibodies to glutamate on pentylenetetrazole-induced acute generalized epileptiform activity in C57Bl/6 mice. The antiepileptic effect was observed 1.5 and 24 h after administration of antibodies to glutamate in doses of 10, 25, and 50 mg/kg. This treatme...

journal_title：Bulletin of experimental biology and medicine

authors： Evseev VA,Karpova MN,Vetrile LA,Klishina NY,Kuznetsova LV,Trekova NA

更新日期：2005-09-01 00:00:00

abstract：:Voltage clamp and concentration jump experiments performed on Purkinje cells isolated from rat cerebellum showed that novel imidazobenzoimidazole derivative RU-353 increased the amplitude of GABA-activated chlorine current in a dose-dependent manner (EC50=15 microM for the currents activated by 1 microM GABA). RU-353 ...

journal_title：Bulletin of experimental biology and medicine

authors： Sharonova NI,Vorob'ev VS,Skrebitskii VG,Galenko-Yaroshevskii AP,Turovaya AY,Anisimova VA

更新日期：2005-09-01 00:00:00

abstract：:We proposed a mathematical model and estimated the parameters of adsorption of albumin-bilirubin complex to the surface of carbon pyropolymer. Design data corresponded to the results of experimental studies. Our findings indicate that modeling of this process should take into account fractal properties of the surface ...

journal_title：Bulletin of experimental biology and medicine

authors： Nikolaev AV,Rozhilo YA,Starozhilova TK,Sarnatskaya VV,Yushko LA,Mikhailovskii SV,Kholodov AS,Lobanov AI

更新日期：2005-09-01 00:00:00

abstract：:We studied the effect of vasopressin analogue desglycinamide-arginine-vasopressin on changes in platelet hemostasis produced by intragastric administration of Ticlid or clopidogrel (inhibitors of ADP-induced platelet aggregation). Intranasal administration of the peptide under conditions of hemorrhagic diathesis produ...

journal_title：Bulletin of experimental biology and medicine

authors： Golubeva MG,Grigoreva ME,Smirnova MP

更新日期：2005-08-01 00:00:00

abstract：:We studied the effect of continuous vibration and treatment with licorice root (Glycyrrhiza glabra L.) on peripheral blood red cells in rabbits. Active substances of licorice root accelerated metabolism in cells of the bone marrow erythroid stem, enhanced compensatory reserve of the organism, and increased animal's re...

journal_title：Bulletin of experimental biology and medicine

authors： Adamyan TI,Gevorkyan ES,Minasyan SM,Oganesyan KR,Kirakosyan KA

更新日期：2005-08-01 00:00:00

abstract：:Carnosine significantly increased the number of spermatogonia and Sertoli cells in mice prone (SAMP1) and resistant (SAMR1) to accelerated aging and appreciably reduced cell yield in meiosis and spermiogenesis in SAMP1 mice. In experimental SAMP1 mice catastrophic changes in the number of gametes were paralleled by in...

journal_title：Bulletin of experimental biology and medicine

authors： Gopko AV,Kulibin AY,Semenova ML,Zakhidov ST

更新日期：2005-08-01 00:00:00

abstract：:Study of the arteriovenous difference in hormone levels and hemostasis parameters in rats with experimental gestosis induced by hyper-sodium diet showed decreased production of progesterone, increased level of hydrocortisone (resultant from its increased production and additional release of the hormone by the lungs), ...

journal_title：Bulletin of experimental biology and medicine

authors： Myasnikova VV,Lysenkov SP,Galenko-Yaroshevskii PA,Barbakidze TR,Sukoyan GV

更新日期：2005-07-01 00:00:00

abstract：:The effect of panavir on Parkinson's syndrome induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine was studied in C57Bl/6 mice and outbred albino rats. Two injections of panavir significantly reduced the severity of oligokinesia and autonomic manifestations of experimentally induced Parkinson's syndrome. ...

journal_title：Bulletin of experimental biology and medicine

authors： Kalinina TS,Nerobkova LN,Voronina TA,Stovbun SV,Litvin AA,Sergienko VI

更新日期：2005-07-01 00:00:00

abstract：:Characteristics of distribution of cholinergic and adrenoceptor structures along the sinoatrial node artery in rat heart were evaluated by autoradiography on semithin sections by determining the density of (3)H-dihydroalprenolol and (3)H-quinuclidinyl benzilate binding sites. The relative density of binding sites for ...

journal_title：Bulletin of experimental biology and medicine

authors： Sutyagin PV,Kalinina EE,Pylaev AS

更新日期：2005-07-01 00:00:00

abstract：:Comparative study of cultured human bone marrow and adipose tissue (lipoaspirate) mesenchymal stem cells was carried out. The main morphological parameters, proliferative activity, expression of surface and intracellular markers of these cells were characterized. Flow cytofluorometry and histological staining showed t...

journal_title：Bulletin of experimental biology and medicine

authors： Romanov YA,Darevskaya AN,Merzlikina NV,Buravkova LB

更新日期：2005-07-01 00:00:00

abstract：:The inotropic response of the myocardium to extrasystolic treatment was studied on isolated perfused papillary muscles from rats with postinfarction cardiosclerosis. The development of postinfarction cardiosclerosis was accompanied by a decrease in myocardial excitability. The amplitude of extrasystolic contractions i...

journal_title：Bulletin of experimental biology and medicine

authors： Kondrat'eva DS,Afanas'ev SA,Falaleeva LP,Shakhov VP

更新日期：2005-06-01 00:00:00